Wednesday, January 1, 2020

How an Alzheimer’s ‘cabal’ thwarted progress toward a cure - STAT

How an Alzheimer’s ‘cabal’ thwarted progress toward a cure - STAT



...The most influential researchers have long believed so dogmatically in one theory of Alzheimer’s that they systematically thwarted alternative approaches. Several scientists described those who controlled the Alzheimer’s agenda as “a cabal.”



.... Several who tried to start companies to develop Alzheimer’s cures were told again and again by venture capital firms and major biopharma companies that they would back only an amyloid approach.

“The amyloid hypothesis has been one of the most tragic stories [in] disease research,” said neurobiologist Rachael Neve of Massachusetts General Hospital.
...neurobiologist at England’s University of Manchester, in 1991 she discovered pathogens — herpes simplex virus type 1 — in the brains of elderly people who had died with Alzheimer’s and carried the most common gene for the disease. It was the first indication that infectious agents might play a role in Alzheimer’s, raising the possibility that eliminating them (and the resulting immune response, including inflammation) might stop or even reverse it.

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