Budget 2024: key points at a glance | Autumn budget 2024 | The Guardian

Budget 2024: key points at a glance | Autumn budget 2024 | The Guardian

A Conversation with Chris Wood and Dr. Michael Roizen Transformative Age - Transcript - Mauldin Economics

Transformative Age - Transcript - Mauldin Economics

https://m.mauldineconomics.com/jm-571-chris-wood-dr-roizen-transcript?itm_campaign=JM-571&itm_content=JM571Z8&itm_medium=ES&itm_source=mec

A Conversation with Chris Wood and Patrick Cox The Transcript Transformative Age - Transcript - Mauldin Economics

Transformative Age - Transcript - Mauldin Economics

https://m.mauldineconomics.com/jm-571-patrick-cox-transcript?itm_campaign=JM-571&itm_content=JM571Z7&itm_medium=ES&itm_source=mec

Exclusive: Dem super PAC unleashes $100M in new ads - btbirkett@gmail.com - Gmail

Exclusive: Dem super PAC unleashes $100M in new ads - btbirkett@gmail.com - Gmail

FIRST IN PLAYBOOK — The pro-KAMALA HARRIS super PAC Future Forward is launching another huge $100 million flight of ads to broadcast her closing message to voters across every major platform in the campaign’s final week. The record-breaking messaging deluge leans heavily into voters’ economic concerns and Harris’ effort to contrast her plans to improve people’s lives with those of DONALD TRUMP.

The two national spots are focused on helping Americans get ahead:

• “Plans” argues, in line with Harris’ speech tonight, that Trump will seek personal revenge while Harris “fights for you.”

• “Get By” targets Black voters with specific dollar promises on home-buying and small businesses, while making sure to needle Trump’s viral “Black jobs” comment.

Across the swing states, Future Forward’s other ads seek to shore up the various parts of the coalition Democrats need, from Spanish speakers to football fans to pro-abortion-rights women, with a heavy dose of economic populism.

“Kay” slams Trump over Social Security and Medicare. … “Jackie” shows a former Trump voter drawing an economic contrast between the candidates. … “Steven - Elon” highlights a steelworker who criticizes Trump for palling around with billionaires like ELON MUSK. … “Who You Trust” pairs a tax-cut message with an abortion focus in an overall freedom message. … “Backs” inverts one of Trump’s most famous ads by concluding, “She’s with us, not with them.” (This time, “them” is Trump and Musk, instead of people who are transgender or non-binary.) … “Right” emphasizes no new taxes for the vast majority of Americans under Harris.

On Spanish-language radio, the musical “Puro Engaño” spot ties Trump to Project 2025 and health care cuts. On English-language radio, “Sales Tax of Doom” warns specifically that Trump’s tariffs would cost people $4,000 to $5,000 annually. And Future Forward also has a slate of digital ads focused on the economy: “Always,” “Tax Hikes,” “Beyond - Taxes,” “Beyond - Social Security,” “Amanda” and “Fight.”

MabLab's improved drug and drink testing strips could make for safer streets and venues | TechCrunch

MabLab's improved drug and drink testing strips could make for safer streets and venues | TechCrunch

MabLab’s improved drug and drink testing strips could make for safer streets and venues

Devin Coldewey

2:53 PM PDT · October 28, 2024

For anyone who parties or goes out dancing, the risk of accidentally taking adulterated drugs is a real one. MabLab, presenting today on the Startup Battlefield stage at TechCrunch Disrupt 2024, has created a testing strip that detects the five most common and dangerous additives in minutes.

Co-founders Vienna Sparks and Skye Lam met in high school, and during college the pair lost a friend to overdose. It’s a story that, sadly, many people (including myself) can identify with. Thankfully, testing strips are a common sight now at venues and health centers, with hundreds of millions shipping yearly.

If you haven’t seen them, the strips work like this: You dissolve a bit of the substance to be tested in a provided buffer solution, then dip the strip in. The liquid travels up the paper, reaching a treated area that changes color in the presence of an unwanted additive. They’re simple and effective, but limited in that they only detect one thing, most commonly fentanyl.

“We have an opportunity to replace that with a better version,” said Lam — one that detects five common lacing chemicals simultaneously: fentanyl, methamphetamine, benzodiazepine, xylazine, and methadone.

The company’s innovation is “a mix of physical and chemical,” said Sparks: “There’s a zone specifically designed for each agent, and we’re using novel treatments and materials on the strip to allow capillary action to occur without incurring cross-reactivity.”

That is to say, the different zones and chemical sensitivities won’t set each other off or prevent the others from activating.

Dr. Rosen Transformative Age - Mauldin Economics

Transformative Age - Mauldin Economics

https://m.mauldineconomics.com/jm-571-chris-wood-dr-roizen-video?itm_campaign=JM-571&itm_content=JM571Z2&itm_medium=ES&itm_source=mec

Macroeconomist and longevity expert Patrick Cox on the science of age reversal - Mauldin Economics

Macroeconomist and longevity expert Patrick Cox on the science of age reversal - Mauldin Economics

Broken China - Mauldin Economics

Broken China - Mauldin Economics

CRISPR - Transformative Age Advisory - Transformative Age

Transformative Age Advisory - Transformative AgeFor example, you’ve likely heard of CRISPR—the revolutionary genome editing technology that allows scientists to modify DNA in living organisms.

But what you may not know is that CRISPR is already changing people’s lives.

Just ask Victoria Gray, the first patient with sickle cell disease to receive an experimental CRISPR treatment. Today, all of her symptoms are gone.

Then there’s Aissam Dam, an 11-year-old deaf boy who received a gene editing injection… and can now hear for the first time.

At fourteen, Antonio Carvajal was legally blind. Today, he can see thanks to CRISPR eye drops.

longevity-myths-and-solutions

 https://www.mauldineconomics.com/download/longevity-myths-and-solutions

When he was born in 1919, farm and industrial accidents commonly led to fatal infections. Until the closing days of World War II, dog bites were life-threatening. Then, in 1945, large-scale production of penicillin changed everything. Medical historians estimate that antibiotics account for at least 10 years of the increased lifespans we enjoy today.

...The root of their error was assuming that births were driving population growth. In reality, longer lifespans were the culprit

...true anti-aging medicine will increase healthspans, not just lifespans... Eventually, the final phase of dependency so common now could disappear entirely for everyone who doesn’t reject longevity biotechnologies.

How October 7th changed Israel and the Middle East - GZERO Media

How October 7th changed Israel and the Middle East - GZERO Media

Welcome to the new space economy - btbirkett@gmail.com - Gmail

Welcome to the new space economy - btbirkett@gmail.com - Gmail

Welcome to the new space economy

In this issue: Printing human knees in space iPhone 25: made on the moon! The accidental $20 billion miracle drug Three Mile Island is back Matt Ridley’s crystal ball

Hi Rational Optimist Society member,   Thanks for the big response to last week’s issue. A lot of you are really excited about space tech and the nuclear revival. Me too!   Let’s talk space today. Wait until you see the breakthroughs happening right now, and how they intersect with biotech. This stuff should be front-page news.   I'm reading Liftoff, a book about the early days of Elon Musk’s SpaceX. If you want to be inspired, pick up a copy.   Before Musk was a billionaire, he almost went broke. Several times. His closest brush with bankruptcy was due to SpaceX. He personally invested $100 million. Its first three rockets failed, exploding into million-dollar fireworks. Elon had to borrow money to pay rent.   Here’s Musk staring at a pile of twisted metal from a failed launch:

How am I gonna pay rent?   Today, “just” 22 years later, SpaceX is worth $210 billion. It’s the world’s most valuable private company. Last month, it achieved the first-ever private spacewalk. Here’s a SpaceX astronaut gazing down at Earth:

Does it get more inspirational than this?   Imagine a giant floating laboratory, bigger than a football field, zooming around Earth every 90 minutes. That's the International Space Station (ISS). It has flourished into a bustling factory for groundbreaking medical research that can’t be conducted on Earth.   Researchers aboard the ISS successfully 3D printed the first human knee meniscus (!) last year. Redwire (public: RDW), which owns the BioFabrication lab on the ISS, then sent the meniscus back to Earth aboard a SpaceX rocket.   Why do this in space? In a word, microgravity. Try to make a soft, squishy organ like a human liver on earth. It'll collapse under its own weight like a failed soufflé. No problem in space, where everything is near-weightless.   Right now, 250 miles above our heads, innovation specialists at Airbus are growing mini hearts, livers, and kidneys in space.   Need a new liver? In the not-too-distant future, we'll upload your unique cell samples, use them to print a perfect match in space, and then gently ship your new liver back to Earth.   Microgravity is a game changer for drug development too. Drug particles made on Earth often end up like mixed nuts, all different shapes and sizes. In microgravity, drug molecules can be formed like perfectly round marbles.   For cancer patients, this isn't just a fun fact. Better drugs are life-changing. They’re the difference between spending hours hooked up to an IV drip vs. swallowing a space-made pill at home.   Most major pharma companies already make drugs on the ISS. Last year, the floating lab hosted 500 projects. Merck tested Keytruda in space, a cancer immunotherapy that’s now one of the world’s best-selling drugs.    Progress is happening here fast. Startup Varda (private) recently launched the world's first space-based drug factory. Varda’s capsule hitched a ride on a SpaceX rocket, made some pills in orbit, and then parachuted back to Earth.   Notice every story above involves SpaceX. SpaceX has made the new space economy possible by reducing the cost of rocket launches by 98%.   Imagine if every time you flew, the airline had to build a new plane? Flying from London to NYC would cost $1 million. That's how reaching space used to work.   SpaceX changed the game by pioneering reusable rockets that land themselves after launch, ready for the next trip. In 2000, launching something into space cost as much as $73,000/kg. SpaceX slashed this by 98% to $1,200/kg. Musk is targeting $10/kg!   Don’t underestimate the impact of reducing costs. It’s often how new industries are born. Varda, for example, was never a viable business because it would’ve cost $20 million+ to send its 660lb mini drug factory into orbit 20 years ago. SpaceX delivered it into space for less than $2 million.   Imagine all the Vardas that will be built because we can now get to space for cheap. The iPhone gave us Uber, Netflix, and Facebook. What trillion-dollar ideas will cheap space travel spawn?   SpaceX is essentially running a cosmic taxi. It has launched 11 rockets in the past month alone. Booking a trip to orbit is almost as easy as preordering an Uber.   Seriously. Try it. Visit SpaceX's website, type in the weight of your “parcel” and when you want to send it. You’ll get an instant quote. I see the future.   Thanks to SpaceX, more objects reached space in the past two years than in all of previous history. SpaceX accounts for 95%+ of these launches.

Source: Our World in Data   Where’s this all going? Here’s a prediction: Your iPhone 25 will be made on the moon. Don’t laugh.   The “switches” on the chip inside your iPhone are so tiny that 20,000 of them fit on the width of a human hair. They can only be manufactured in an extremely clean environment. A single speck of dust ruins them. Today, we deal with this by building $20 billion factories with state-of-the-art air filtration systems.   Mother Nature provides “clean rooms” for free in space. It's a near-perfect vacuum, no air, no dust. And it's cold, with temperatures dipping as low as -65 degrees. That's great for chips, which generate enough heat to fry an egg when they're working hard.   The moon could become the Silicon Valley of space. Imagine chipmakers setting up shop next to where Neil Armstrong planted the American flag.   One day, we'll look back and laugh that humans had to make everything on Earth.    “We choose to go to the moon, not because it is easy, but because it is hard.” That was JFK in 1962. America put a man on the moon seven years later.   Optimism is contagious. It spreads from person to person, lighting up imaginations and firing up ambitions like a chain reaction.   The next time you look up at the night sky, remember you're not just stargazing. You're looking at the factories and workshops of the future. The cure for cancer might take shape up there.

lacy-hunt-recommended-reading

 https://www.mauldineconomics.com/download/lacy-hunt-recommended-reading

3-buckets-of-biotech-profits

 https://www.mauldineconomics.com/download/3-buckets-of-biotech-profits

... “With 80% probability, soon you’ll be able to be physiologically 40 at calendar age 90.” I’ve heard similar claims from other medical doctors and research scientists in my professional network. 

That might sound outlandish but consider how far we have already come. Life expectancy in the US has basically doubled in the past 150 years...